BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 11,591

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.07%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.6%
Services
Technology
Transportation
Utilities

125 Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
ALDER BIOPHARMACEUTICALS INC COM 36,898 30,465 473.58 879,581
DBV TECHNOLOGIES S A SPONSORED ADR 36,082 New 1,519,229
INSMED INC COM PAR $.01 35,391 10,631 42.93 1,583,490
TG THERAPEUTICS INC COM 32,846 New 2,050,313
HERON THERAPEUTICS INC COM 31,632 New 2,607,784
CATALYST PHARM PARTNERS INC COM 29,884 3,358 12.66 7,565,462
GILEAD SCIENCES INC COM 28,114 -687 (2.39) 249,995
BLUEBIRD BIO INC COM 27,805 -649 (2.28) 146,581
FOAMIX PHARMACEUTICALS LTD SHS 24,724 10,861 78.34 1,821,967
IDERA PHARMACEUTICALS INC COM NEW 24,309 18,627 327.81 6,965,432
PROGENICS PHARMACEUTICALS INC COM 24,103 -548 (2.23) 4,350,808
NEUROCRINE BIOSCIENCES INC COM 23,284 -530 (2.23) 542,236
ACORDA THERAPEUTICS INC COM 23,268 -523 (2.2) 738,916
DERMA SCIENCES INC COM PAR $.01 22,683 -520 (2.24) 3,457,841
CLOVIS ONCOLOGY INC COM 19,007 New 202,630
AGIOS PHARMACEUTICALS INC COM 18,479 -1,656 (8.23) 149,954
VANDA PHARMACEUTICALS INC COM 17,765 -27,628 (60.86) 1,750,230
KYTHERA BIOPHARMACEUTICALS INC COM 17,703 3,398 23.76 354,265
NOVAVAX INC COM 17,492 6,494 59.04 1,945,687
SANGAMO BIOSCIENCES INC COM 17,206 5,503 47.02 1,404,544


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