BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2014

Position Statistics

Total Positions 102
New Positions 8
Increased Positions 28
Decreased Positions 18
Positions with Activity 46
Sold Out Positions 6
Total Mkt Value (in $ millions) 7,527

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.04%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.1%
Services
Technology
Transportation
Utilities

102 Positions as of 09/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
GILEAD SCIENCES INC COM 26,681 New 256,108
REPROS THERAPEUTICS INC COM NEW 24,091 New 2,778,654
VERSARTIS INC COM 23,078 4 .02 1,246,089
CATALYST PHARM PARTNERS INC COM 22,967 15,364 202.08 6,715,462
MALLINCKRODT PUB LTD CO SHS 21,950 -26,820 (54.99) 201,856
HERON THERAPEUTICS INC COM 21,801 New 2,607,784
AGIOS PHARMACEUTICALS INC COM 20,511 -3,622 (15.01) 169,893
NEUROCRINE BIOSCIENCES INC COM 19,050 New 554,590
OMEROS CORP COM 18,893 1,284 7.29 808,775
INSMED INC COM PAR $.01 17,681 12,829 264.36 1,107,850
DAIICHI SANKYO CO LTD SPON ADR LEV 1 15,602 4,929 46.18 1,093,332
BLUEBIRD BIO INC COM 14,769 -4,752 (24.34) 150,000
AQUINOX PHARMACEUTICALS INC COM 13,027 New 1,211,851
TEKMIRA PHARMACEUTICALS CORP COM NEW 12,714 New 484,156
KYTHERA BIOPHARMACEUTICALS INC COM 11,993 New 311,255
SANGAMO BIOSCIENCES INC COM 11,416 4,516 65.44 864,856
ARRAY BIOPHARMA INC COM 10,696 New 1,433,797
MACROGENICS INC COM 9,815 New 311,891
NOVAVAX INC COM 9,616 New 1,223,362
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 9,267 4,396 90.24 421,631