BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2015

Position Statistics

Total Positions 127
New Positions 5
Increased Positions 30
Decreased Positions 12
Positions with Activity 42
Sold Out Positions 7
Total Mkt Value (in $ millions) 9,143

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.69%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.16%
Services
Technology
Transportation
Utilities

7 Sold Out Positions as of 12/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
ALDER BIOPHARMACEUTICALS INC COM -13,632 Sold Out 0
BELLEROPHON THERAPEUTICS INC COM -695 Sold Out 0
CLOVIS ONCOLOGY INC COM -2,819 Sold Out 0
REPROS THERAPEUTICS INC COM NEW -4,636 Sold Out 0
SYNERGY PHARMACEUTICALS DEL COM NEW -211 Sold Out 0
THRESHOLD PHARMACEUTICAL INC COM NEW -1,287 Sold Out 0
ZAFGEN INC COM -2,487 Sold Out 0