BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 10,857

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.16%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.09%
Services
Technology
Transportation
Utilities

17 New Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
INVITAE CORP COM 99,111 99,111 New 6,554,967
SPARK THERAPEUTICS INC COM 78,904 78,904 New 1,327,451
IMMUNOGEN INC COM 14,003 14,003 New 999,496
LION BIOTECHNOLOGIES INC COM 11,892 11,892 New 1,325,000
AMARIN CORP PLC SPONS ADR NEW 5,558 5,558 New 2,205,710
ASSEMBLY BIOSCIENCES INC COM 4,738 4,738 New 250,000
ZAFGEN INC COM 3,312 3,312 New 94,745
INTRA CELLULAR THERAPIES INC COM 3,245 3,245 New 104,166
BELLEROPHON THERAPEUTICS INC COM 2,800 2,800 New 350,000
VITAE PHARMACEUTICALS INC COM 2,313 2,313 New 187,597
ASCENDIS PHARMA A S SPONSORED ADR 1,844 1,844 New 100,000
CELLECTIS S A SPONSORED ADS 1,747 1,747 New 50,000
TRANSITION THERAPEUTICS INC COM NEW 1,669 1,669 New 769,230
ALDEYRA THERAPEUTICS INC COM 1,207 1,207 New 142,000
OHR PHARMACEUTICAL INC COM NEW 919 919 New 370,370
AEGERION PHARMACEUTICALS INC COM 266 266 New 14,300
BIODEL INC COM NEW 30 30 New 30,179