BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 11,502

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.9%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.81%
Services
Technology
Transportation
Utilities

17 New Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
INVITAE CORP COM 90,459 90,459 New 6,554,967
SPARK THERAPEUTICS INC COM 89,643 89,643 New 1,327,451
LION BIOTECHNOLOGIES INC COM 14,270 14,270 New 1,325,000
IMMUNOGEN INC COM 8,886 8,886 New 999,496
TRANSITION THERAPEUTICS INC COM NEW 5,315 5,315 New 769,230
AMARIN CORP PLC SPONS ADR NEW 4,235 4,235 New 2,205,710
ASSEMBLY BIOSCIENCES INC COM 3,718 3,718 New 250,000
BELLEROPHON THERAPEUTICS INC COM 3,168 3,168 New 350,000
ZAFGEN INC COM 2,963 2,963 New 94,745
INTRA CELLULAR THERAPIES INC COM 2,603 2,603 New 104,166
VITAE PHARMACEUTICALS INC COM 2,371 2,371 New 187,597
ASCENDIS PHARMA A S SPONSORED ADR 1,766 1,766 New 100,000
CELLECTIS S A SPONSORED ADS 1,700 1,700 New 50,000
OHR PHARMACEUTICAL INC COM NEW 1,033 1,033 New 370,370
ALDEYRA THERAPEUTICS INC COM 1,012 1,012 New 142,000
AEGERION PHARMACEUTICALS INC COM 291 291 New 14,300
BIODEL INC COM NEW 33 33 New 30,179