BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2014

Position Statistics

Total Positions 109
New Positions 14
Increased Positions 27
Decreased Positions 13
Positions with Activity 40
Sold Out Positions 1
Total Mkt Value (in $ millions) 9,003

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.08%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 95.12%
Services
Technology
Transportation
Utilities

14 New Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
BELLICUM PHARMACEUTICALS INC COM 98,911 98,911 New 4,283,732
DBV TECHNOLOGIES S A SPONSORED ADR 41,353 41,353 New 1,519,229
CLOVIS ONCOLOGY INC COM 16,608 16,608 New 202,630
SUNESIS PHARMACEUTICALS INC COM NEW 7,360 7,360 New 3,200,000
CHIMERIX INC COM 6,279 6,279 New 172,414
JUNO THERAPEUTICS INC COM 4,507 4,507 New 100,000
NEURODERM LTD ORD SHS 3,128 3,128 New 250,000
APTOSE BIOSCIENCES INC COM NEW 2,616 2,616 New 479,164
PROTEON THERAPEUTICS INC COM 2,400 2,400 New 172,917
PALATIN TECHNOLOGIES INC COM PAR $ .01 1,923 1,923 New 2,050,000
ALCOBRA LTD SHS 1,681 1,681 New 289,871
DERMIRA INC COM 1,460 1,460 New 100,000
ASTERIAS BIOTHERAPEUTICS INC COM SER A 197 197 New 16,775
BIOTIME INC WT EXP 100118 50 50 New 20,525