BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2015

Position Statistics

Total Positions 127
New Positions 5
Increased Positions 30
Decreased Positions 12
Positions with Activity 42
Sold Out Positions 7
Total Mkt Value (in $ millions) 9,398

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.69%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92.09%
Services
Technology
Transportation
Utilities

30 INCREASED Positions as of 12/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
SHIRE PLC SPONSORED ADR 1,508,351 135,867 9.90 8,310,017
INCYTE CORP COM 1,425,398 25 .00 19,475,316
SEATTLE GENETICS INC COM 1,419,772 48,120 3.51 37,293,728
GENOMIC HEALTH INC COM 383,006 26 .01 13,659,264
BIOMARIN PHARMACEUTICAL INC COM 360,975 3,397 .95 4,115,083
ANACOR PHARMACEUTICALS INC COM 281,637 4,233 1.53 4,198,520
ACORDA THERAPEUTICS INC COM 103,501 71,790 226.39 3,580,112
BELLICUM PHARMACEUTICALS INC COM 50,749 7,041 16.11 4,865,647
BIOCRYST PHARMACEUTICALS COM 47,203 357 .76 14,217,779
NEUROCRINE BIOSCIENCES INC COM 39,338 4,624 13.32 850,739
IMMUNOGEN INC COM 37,846 7,687 25.49 4,452,445
SANGAMO BIOSCIENCES INC COM 25,917 1,917 7.99 4,055,876
ADVANCED ACCELERATOR APPLIC SPONSORED ADS 19,515 19,515 New 567,454
DERMA SCIENCES INC COM PAR $.01 13,490 1,059 8.52 3,752,390
IDERA PHARMACEUTICALS INC COM NEW 12,360 12 .10 6,983,107
ALKERMES PLC SHS 10,153 10,153 New 250,251
DIMENSION THERAPEUTICS INC COM 10,135 10,135 New 1,234,481
ALCOBRA LTD SHS 9,719 2,897 42.47 2,336,359
ASCENDIS PHARMA A S SPONSORED ADR 8,730 1,209 16.07 505,521
GLOBAL BLOOD THERAPEUTICS INC COM 8,416 4,208 100 400,000


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