BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2014

Position Statistics

Total Positions 109
New Positions 14
Increased Positions 27
Decreased Positions 13
Positions with Activity 40
Sold Out Positions 1
Total Mkt Value (in $ millions) 9,381

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.06%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 94.93%
Services
Technology
Transportation
Utilities

27 INCREASED Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
SEATTLE GENETICS INC COM 1,006,644 194,596 23.96 27,861,720
BIOMARIN PHARMACEUTICAL INC COM 449,054 162,441 56.68 3,713,950
GENOMIC HEALTH INC COM 414,879 21 .01 13,656,318
BELLICUM PHARMACEUTICALS INC COM 110,606 110,606 New 4,283,732
XENOPORT INC COM 49,292 627 1.29 6,903,628
VANDA PHARMACEUTICALS INC COM 44,274 990 2.29 4,472,153
VERSARTIS INC COM 43,376 19,688 83.11 2,281,744
DBV TECHNOLOGIES S A SPONSORED ADR 38,011 38,011 New 1,519,229
ACORDA THERAPEUTICS INC COM 26,058 74 .28 755,534
CLOVIS ONCOLOGY INC COM 17,457 17,457 New 202,630
SANGAMO BIOSCIENCES INC COM 13,852 1,312 10.46 955,332
XENCOR INC COM 8,794 729 9.04 591,371
SUNESIS PHARMACEUTICALS INC COM NEW 8,448 8,448 New 3,200,000
CONCERT PHARMACEUTICALS INC COM 7,581 809 11.94 505,418
CHIMERIX INC COM 6,631 6,631 New 172,414
JUNO THERAPEUTICS INC COM 6,466 6,466 New 100,000
FOUNDATION MEDICINE INC COM 6,253 2,379 61.39 126,147
IDERA PHARMACEUTICALS INC COM NEW 5,617 31 .55 1,628,172
NEURODERM LTD ORD SHS 3,453 3,453 New 250,000
APTOSE BIOSCIENCES INC COM NEW 3,110 3,110 New 479,164