BAKER BROS ADVISORS LLC
667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600
Report Date: 03/31/2013
Position Statistics:
| Total Positions | 67 |
| New Positions | 8 |
| Increased Positions | 20 |
| Decreased Positions | 16 |
| Positions with Activity | 36 |
| Sold Out Positions | 5 |
| Total Mkt Value (in $ millions) |
3,932 |
Sector Weighting
| Basic Materials | |
| Capital Goods | |
| Conglomerates | 0.09% |
| Consumer Cyclical | |
| Consumer/Non-Cyclical | |
| Energy | |
| Financial | |
| Healthcare | 99.91% |
| Services | |
| Technology | |
| Transportation | |
| Utilities |
Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.
20 INCREASED Positions as of 03/31/2013
| Company | Class | Value of Shares ($1,000s) |
Change in Value ($1,000s) | Change (%) | Shares Held |
|---|---|---|---|---|---|
| GENOMIC HEALTH INC | COM | 468,378 | 8,098 | 1.76 | 12,577,272 |
| SYNAGEVA BIOPHARMA CORP | COM | 364,500 | 33,976 | 10.28 | 9,223,182 |
| AEGERION PHARMACEUTICALS INC | COM | 51,842 | 14,960 | 40.56 | 863,743 |
| BIOMARIN PHARMACEUTICAL INC | COM | 50,915 | 37,887 | 290.81 | 783,311 |
| ARIAD PHARMACEUTICALS INC | COM | 37,690 | 367 | .98 | 2,150,000 |
| CERUS CORP | COM | 35,397 | 23,984 | 210.16 | 6,542,845 |
| REPROS THERAPEUTICS INC | COM NEW | 35,319 | 11,919 | 50.94 | 2,261,154 |
| HALOZYME THERAPEUTICS INC | COM | 24,153 | 10,721 | 79.81 | 3,182,251 |
| VERTEX PHARMACEUTICALS INC | COM | 20,058 | 20,058 | New | 252,400 |
| VANDA PHARMACEUTICALS INC | COM | 13,736 | 10,191 | 287.48 | 1,937,390 |
| QUESTCOR PHARMACEUTICALS INC | COM | 12,708 | 12,708 | New | 341,513 |
| QLT INC | COM | 12,179 | 596 | 5.15 | 1,535,863 |
| IRONWOOD PHARMACEUTICALS INC | COM CL A | 9,417 | 9,417 | New | 698,058 |
| INSMED INC | COM PAR $.01 | 9,016 | 6,295 | 231.35 | 795,803 |
| CHELSEA THERAPEUTICS INTL LTD | COM | 8,787 | 3,199 | 57.23 | 4,775,787 |
| STEMLINE THERAPEUTICS INC | COM | 7,250 | 7,250 | New | 500,000 |
| ACHILLION PHARMACEUTICALS INC | COM | 3,526 | 3,526 | New | 455,000 |
| PROTHENA CORP PLC | SHS | 2,022 | 2,022 | New | 191,696 |
| AVEO PHARMACEUTICALS INC | COM | 1,508 | 1,508 | New | 519,833 |
| TESARO INC | COM | 1,116 | 1,116 | New | 31,218 |
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