BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2014

Position Statistics

Total Positions 101
New Positions 17
Increased Positions 36
Decreased Positions 51
Positions with Activity 87
Sold Out Positions 6
Total Mkt Value (in $ millions) 5,370

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.11%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.59%
Services
Technology
Transportation
Utilities

36 INCREASED Positions as of 03/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
PHARMACYCLICS INC COM 913,109 1,951 .21 8,737,888
SYNAGEVA BIOPHARMA CORP COM 801,169 28,215 3.65 10,648,182
SEATTLE GENETICS INC COM 719,451 121 .02 20,739,426
INCYTE CORP COM 711,365 1,199 .17 14,835,559
ACADIA PHARMACEUTICALS COM 426,628 10,963 2.64 20,481,442
GENOMIC HEALTH INC COM 363,883 88 .02 13,654,150
INTERMUNE INC COM 198,640 191,751 2,783.23 4,324,843
XOMA CORP DEL COM 93,844 103 .11 23,057,572
ANACOR PHARMACEUTICALS INC COM 53,673 10,323 23.81 3,095,318
DERMA SCIENCES INC COM PAR $.01 34,912 9,656 38.23 3,537,137
AVANIR PHARMACEUTICALS INC CL A NEW 30,514 1,905 6.66 5,790,139
ACORDA THERAPEUTICS INC COM 29,560 29,560 New 1,000,000
DYAX CORP COM 22,887 4,567 24.93 2,531,766
PROGENICS PHARMACEUTICALS INC COM 22,471 1,261 5.95 4,449,797
HERON THERAPEUTICS INC COM 19,792 19,792 New 2,167,784
XENOPORT INC COM 17,669 13,140 290.10 4,034,112
AEGERION PHARMACEUTICALS INC COM 14,950 405 2.78 513,922
OMEROS CORP COM 10,591 2,043 23.90 753,804
AQUINOX PHARMACEUTICALS INC COM 9,695 9,695 New 1,211,851
GALECTIN THERAPEUTICS INC COM NEW 6,860 5,480 397.02 500,000


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