BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2016

Position Statistics

Total Positions 125
New Positions 5
Increased Positions 34
Decreased Positions 13
Positions with Activity 47
Sold Out Positions 5
Total Mkt Value (in $ millions) 8,974

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.63%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 91.05%
Services
Technology
Transportation
Utilities

34 INCREASED Positions as of 03/31/2016

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
INCYTE CORP COM 1,895,856 324,587 20.66 23,498,460
SEATTLE GENETICS INC COM 1,704,334 234,215 15.93 43,235,267
ACADIA PHARMACEUTICALS COM 829,324 127,835 18.22 24,213,838
ANACOR PHARMACEUTICALS INC COM 509,113 91,822 22.00 5,122,375
BIOMARIN PHARMACEUTICAL INC COM 411,002 59,122 16.80 4,806,483
GENOMIC HEALTH INC COM 348,053 14 .00 13,659,832
DBV TECHNOLOGIES S A SPONSORED ADR 169,970 1,467 .87 5,509,560
ACORDA THERAPEUTICS INC COM 97,568 2,158 2.26 3,661,082
MIRATI THERAPEUTICS INC COM 55,108 5,285 10.61 3,268,556
BEIGENE LTD SPONSORED ADR 53,211 53,211 New 1,912,680
AQUINOX PHARMACEUTICALS INC COM 53,105 6,885 14.90 7,752,487
BIOCRYST PHARMACEUTICALS COM 48,334 2,553 5.58 15,010,534
NEUROCRINE BIOSCIENCES INC COM 43,043 2,148 5.25 895,422
ACHILLION PHARMACEUTICALS INC COM 21,017 4,037 23.78 2,475,515
ADVANCED ACCELERATOR APPLIC SPONSORED ADS 17,639 1,365 8.39 615,033
INSMED INC COM PAR $.01 17,010 5,670 50 1,500,000
EXELIXIS INC COM 15,480 15,480 New 2,580,000
FOAMIX PHARMACEUTICALS LTD SHS 15,333 1,332 9.51 2,241,702
BLUEBIRD BIO INC COM 14,961 8,980 150.13 352,943
AGIOS PHARMACEUTICALS INC COM 14,959 10,101 207.92 307,915


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