BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2014

Position Statistics

Total Positions 101
New Positions 17
Increased Positions 36
Decreased Positions 51
Positions with Activity 87
Sold Out Positions 6
Total Mkt Value (in $ millions) 5,315

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.12%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 97.59%
Services
Technology
Transportation
Utilities

36 INCREASED Positions as of 03/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
PHARMACYCLICS INC COM 915,905 1,957 .21 8,737,888
SYNAGEVA BIOPHARMA CORP COM 770,715 27,143 3.65 10,648,182
SEATTLE GENETICS INC COM 723,599 122 .02 20,739,426
INCYTE CORP COM 701,722 1,183 .17 14,835,559
ACADIA PHARMACEUTICALS COM 422,327 10,853 2.64 20,481,442
GENOMIC HEALTH INC COM 364,975 89 .02 13,654,150
INTERMUNE INC COM 196,780 189,955 2,783.23 4,324,843
XOMA CORP DEL COM 90,616 99 .11 23,057,572
ANACOR PHARMACEUTICALS INC COM 51,599 9,924 23.81 3,095,318
DERMA SCIENCES INC COM PAR $.01 34,063 9,421 38.23 3,537,137
AVANIR PHARMACEUTICALS INC CL A NEW 30,225 1,887 6.66 5,790,139
ACORDA THERAPEUTICS INC COM 29,510 29,510 New 1,000,000
DYAX CORP COM 22,609 4,512 24.93 2,531,766
PROGENICS PHARMACEUTICALS INC COM 22,605 1,269 5.95 4,449,797
HERON THERAPEUTICS INC COM 19,857 19,857 New 2,167,784
XENOPORT INC COM 17,387 12,930 290.10 4,034,112
AEGERION PHARMACEUTICALS INC COM 15,418 418 2.78 513,922
OMEROS CORP COM 10,538 2,033 23.90 753,804
AQUINOX PHARMACEUTICALS INC COM 9,695 9,695 New 1,211,851
GALECTIN THERAPEUTICS INC COM NEW 7,660 6,119 397.02 500,000