BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2014

Position Statistics

Total Positions 103
New Positions 8
Increased Positions 29
Decreased Positions 18
Positions with Activity 47
Sold Out Positions 6
Total Mkt Value (in $ millions) 7,195

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.91%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.24%
Services
Technology
Transportation
Utilities

29 INCREASED Positions as of 09/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
PHARMACYCLICS INC COM 1,269,360 8,551 .68 9,656,599
SEATTLE GENETICS INC COM 739,227 115 .02 22,475,729
GENOMIC HEALTH INC COM 427,557 22 .01 13,655,618
AVANIR PHARMACEUTICALS INC CL A NEW 353,423 40,713 13.02 20,974,677
BIOMARIN PHARMACEUTICAL INC COM 222,444 43,376 24.22 2,370,464
ANACOR PHARMACEUTICALS INC COM 140,479 31,962 29.45 4,204,702
DYAX CORP COM 94,276 7,296 8.39 6,157,789
XOMA CORP DEL COM 92,517 22 .02 23,071,472
CERUS CORP COM 76,537 10,856 16.53 11,940,178
XENOPORT INC COM 55,889 22,810 68.95 6,815,777
VERSARTIS INC COM 24,785 4 .02 1,246,089
CATALYST PHARM PARTNERS INC COM 19,408 12,983 202.08 6,715,462
OMEROS CORP COM 18,707 1,271 7.29 808,775
INSMED INC COM PAR $.01 18,191 13,198 264.36 1,107,850
DAIICHI SANKYO CO LTD SPON ADR LEV 1 15,466 4,886 46.18 1,093,332
SANGAMO BIOSCIENCES INC COM 13,284 5,255 65.44 864,856
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 8,496 4,030 90.24 421,631
PROQR THRAPEUTICS N V SHS EURO 8,100 8,100 New 400,000
ULTRAGENYX PHARMACEUTICAL INC COM 7,257 2,419 50 150,000
CELLADON CORP COM 6,979 6,979 New 375,000


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