BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2014

Position Statistics

Total Positions 102
New Positions 8
Increased Positions 28
Decreased Positions 18
Positions with Activity 46
Sold Out Positions 6
Total Mkt Value (in $ millions) 7,594

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.01%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.11%
Services
Technology
Transportation
Utilities

18 DECREASED Positions as of 09/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
BIOCRYST PHARMACEUTICALS COM 118,493 -1,960 (1.63) 10,713,686
ACORDA THERAPEUTICS INC COM 32,923 -6,673 (16.85) 753,391
TG THERAPEUTICS INC COM 32,067 -1,731 (5.12) 2,050,313
MALLINCKRODT PUB LTD CO SHS 21,665 -26,472 (54.99) 201,856
AGIOS PHARMACEUTICALS INC COM 21,430 -3,784 (15.01) 169,893
BLUEBIRD BIO INC COM 14,604 -4,699 (24.34) 150,000
ARROWHEAD RESH CORP COM NEW 8,333 -1,354 (13.98) 1,230,802
IRONWOOD PHARMACEUTICALS INC COM CL A 5,770 -1,667 (22.41) 346,160
INFINITY PHARMACEUTICALS INC COM 4,942 -4,942 (50) 312,025
SYNERGY PHARMACEUTICALS DEL COM NEW 2,929 -2,363 (44.65) 973,245
BIODELIVERY SCIENCES INTL INC COM 2,917 -2,931 (50.11) 210,021
SALIX PHARMACEUTICALS INC COM 1,089 -15,800 (93.55) 8,621
AEGERION PHARMACEUTICALS INC COM -10,199 Sold Out 0
ASTERIAS BIOTHERAPEUTICS INC COM SER A -71 Sold Out 0
BIOTIME INC WT EXP 100118 -25 Sold Out 0
CLOVIS ONCOLOGY INC COM -54,292 Sold Out 0
GALECTIN THERAPEUTICS INC COM NEW -1,071 Sold Out 0
REGADO BIOSCIENCES INC COM -440 Sold Out 0