BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2014

Position Statistics

Total Positions 103
New Positions 8
Increased Positions 29
Decreased Positions 18
Positions with Activity 47
Sold Out Positions 6
Total Mkt Value (in $ millions) 7,047

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.84%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.62%
Services
Technology
Transportation
Utilities

18 DECREASED Positions as of 09/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
BIOCRYST PHARMACEUTICALS COM 121,922 -2,016 (1.63) 10,713,686
TG THERAPEUTICS INC COM 30,755 -1,660 (5.12) 2,050,313
ACORDA THERAPEUTICS INC COM 27,732 -5,621 (16.85) 753,391
MALLINCKRODT PUB LTD CO SHS 18,498 -22,602 (54.99) 201,856
AGIOS PHARMACEUTICALS INC COM 17,404 -3,073 (15.01) 169,893
ARROWHEAD RESH CORP COM NEW 7,114 -1,156 (13.98) 1,230,802
BLUEBIRD BIO INC COM 6,299 -2,026 (24.34) 150,000
IRONWOOD PHARMACEUTICALS INC COM CL A 4,905 -1,417 (22.41) 346,160
INFINITY PHARMACEUTICALS INC COM 4,755 -4,755 (50) 312,025
BIODELIVERY SCIENCES INTL INC COM 3,318 -3,334 (50.11) 210,021
SYNERGY PHARMACEUTICALS DEL COM NEW 2,998 -2,418 (44.65) 973,245
SALIX PHARMACEUTICALS INC COM 890 -12,917 (93.55) 8,621
AEGERION PHARMACEUTICALS INC COM -9,040 Sold Out 0
ASTERIAS BIOTHERAPEUTICS INC COM SER A -65 Sold Out 0
BIOTIME INC WT EXP 100118 -21 Sold Out 0
CLOVIS ONCOLOGY INC COM -38,233 Sold Out 0
GALECTIN THERAPEUTICS INC COM NEW -1,275 Sold Out 0
REGADO BIOSCIENCES INC COM -334 Sold Out 0


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