BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2014

Position Statistics

Total Positions 110
New Positions 14
Increased Positions 28
Decreased Positions 13
Positions with Activity 41
Sold Out Positions 1
Total Mkt Value (in $ millions) 8,783

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.02%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 94.87%
Services
Technology
Transportation
Utilities

13 DECREASED Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
PHARMACYCLICS INC COM 2,104,105 -121,548 (5.46) 9,129,231
XOMA CORP DEL COM 62,280 -22,623 (26.65) 16,924,013
CERUS CORP COM 52,194 -1,059 (1.99) 11,702,727
REPROS THERAPEUTICS INC COM NEW 19,420 -7,561 (28.02) 2,000,000
AGIOS PHARMACEUTICALS INC COM 17,503 -696 (3.83) 163,393
OMEROS CORP COM 16,980 -4,210 (19.87) 648,101
AQUINOX PHARMACEUTICALS INC COM 12,346 -15 (0.12) 1,210,350
KYTHERA BIOPHARMACEUTICALS INC COM 11,422 -998 (8.03) 286,255
THRESHOLD PHARMACEUTICAL INC COM NEW 9,937 -12 (0.12) 2,155,516
MALLINCKRODT PUB LTD CO SHS 5,422 -18,032 (76.88) 46,666
EPIZYME INC COM 4,849 -289 (5.63) 201,963
ZIOPHARM ONCOLOGY INC COM 2,583 -680 (20.84) 193,640
DAIICHI SANKYO CO LTD SPON ADR LEV 1 -17,417 Sold Out 0