BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 12/31/2014

Position Statistics

Total Positions 110
New Positions 14
Increased Positions 28
Decreased Positions 13
Positions with Activity 41
Sold Out Positions 1
Total Mkt Value (in $ millions) 8,988

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.15%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 94.91%
Services
Technology
Transportation
Utilities

41 Activity Positions as of 12/31/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
PHARMACYCLICS INC COM 2,336,627 -134,980 (5.46) 9,129,231
SEATTLE GENETICS INC COM 984,912 190,395 23.96 27,861,720
BIOMARIN PHARMACEUTICAL INC COM 462,832 167,425 56.68 3,713,950
GENOMIC HEALTH INC COM 417,201 21 .01 13,656,318
SALIX PHARMACEUTICALS INC COM 109,790 108,300 7,269.46 635,321
BELLICUM PHARMACEUTICALS INC COM 99,254 99,254 New 4,283,732
XOMA CORP DEL COM 61,603 -22,377 (26.65) 16,924,013
XENOPORT INC COM 49,154 625 1.29 6,903,628
CERUS CORP COM 48,800 -990 (1.99) 11,702,727
VERSARTIS INC COM 41,916 19,025 83.11 2,281,744
VANDA PHARMACEUTICALS INC COM 41,591 930 2.29 4,472,153
DBV TECHNOLOGIES S A SPONSORED ADR 35,489 35,489 New 1,519,229
ACORDA THERAPEUTICS INC COM 25,144 71 .28 755,534
REPROS THERAPEUTICS INC COM NEW 17,180 -6,689 (28.02) 2,000,000
AGIOS PHARMACEUTICALS INC COM 15,408 -613 (3.83) 163,393
CLOVIS ONCOLOGY INC COM 15,041 15,041 New 202,630
SANGAMO BIOSCIENCES INC COM 14,980 1,419 10.46 955,332
KYTHERA BIOPHARMACEUTICALS INC COM 14,356 -1,254 (8.03) 286,255
OMEROS CORP COM 14,278 -3,540 (19.87) 648,101
AQUINOX PHARMACEUTICALS INC COM 9,949 -12 (0.12) 1,210,350