BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2015

Position Statistics

Total Positions 124
New Positions 8
Increased Positions 32
Decreased Positions 28
Positions with Activity 60
Sold Out Positions 9
Total Mkt Value (in $ millions) 8,984

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.21%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 92%
Services
Technology
Transportation
Utilities

60 Activity Positions as of 06/30/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
INCYTE CORP COM 1,727,229 2,324 .14 14,865,559
SEATTLE GENETICS INC COM 1,243,145 80,280 6.90 30,870,262
ALEXION PHARMACEUTICALS INC COM 1,126,570 -194,769 (14.74) 6,542,599
ABBVIE INC COM 897,053 -41,661 (4.44) 14,373,538
BIOMARIN PHARMACEUTICAL INC COM 529,270 -13,597 (2.51) 4,095,247
ANACOR PHARMACEUTICALS INC COM 472,801 -75,534 (13.78) 3,625,498
GENOMIC HEALTH INC COM 375,857 18 .01 13,657,598
DYAX CORP COM 182,471 43,856 31.64 7,926,630
BIOCRYST PHARMACEUTICALS COM 134,760 12,793 10.49 11,577,299
HERON THERAPEUTICS INC COM 107,987 7,692 7.67 2,807,784
DBV TECHNOLOGIES S A SPONSORED ADR 72,675 13,379 22.56 1,862,019
SPARK THERAPEUTICS INC COM 55,052 -2,838 (4.9) 1,262,382
VERSARTIS INC COM 44,573 5,956 15.42 3,436,585
ALDER BIOPHARMACEUTICALS INC COM 34,553 469 1.38 891,688
ATYR PHARMA INC COM 33,813 33,813 New 2,335,125
HALOZYME THERAPEUTICS INC COM 33,716 -5,536 (14.11) 1,931,057
ARRAY BIOPHARMA INC COM 32,347 -1,040 (3.12) 5,482,505
IMMUNOGEN INC COM 31,233 17,780 132.16 2,320,424
KYTHERA BIOPHARMACEUTICALS INC COM 28,972 2,501 9.45 387,741
CATALYST PHARMACEUTICALS INC COM 26,629 -834 (3.04) 7,335,692


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