BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2014

Position Statistics

Total Positions 103
New Positions 8
Increased Positions 29
Decreased Positions 18
Positions with Activity 47
Sold Out Positions 6
Total Mkt Value (in $ millions) 6,808

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.88%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.57%
Services
Technology
Transportation
Utilities

47 Activity Positions as of 09/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
PHARMACYCLICS INC COM 1,355,111 9,129 .68 9,656,599
SEATTLE GENETICS INC COM 828,231 129 .02 22,475,729
GENOMIC HEALTH INC COM 452,957 24 .01 13,655,618
AVANIR PHARMACEUTICALS INC CL A NEW 291,129 33,537 13.02 20,974,677
BIOMARIN PHARMACEUTICAL INC COM 203,457 39,674 24.22 2,370,464
ANACOR PHARMACEUTICALS INC COM 135,518 30,833 29.45 4,204,702
BIOCRYST PHARMACEUTICALS COM 110,672 -1,830 (1.63) 10,713,686
XOMA CORP DEL COM 105,898 25 .02 23,071,472
DYAX CORP COM 81,714 6,324 8.39 6,157,789
XENOPORT INC COM 54,117 22,086 68.95 6,815,777
CERUS CORP COM 50,865 7,215 16.53 11,940,178
TG THERAPEUTICS INC COM 30,283 -1,634 (5.12) 2,050,313
ACORDA THERAPEUTICS INC COM 27,077 -5,488 (16.85) 753,391
VERSARTIS INC COM 22,330 4 .02 1,246,089
CATALYST PHARM PARTNERS INC COM 17,695 11,837 202.08 6,715,462
MALLINCKRODT PUB LTD CO SHS 17,566 -21,463 (54.99) 201,856
DAIICHI SANKYO CO LTD SPON ADR LEV 1 16,298 5,149 46.18 1,093,332
OMEROS CORP COM 16,273 1,106 7.29 808,775
AGIOS PHARMACEUTICALS INC COM 16,113 -2,845 (15.01) 169,893
INSMED INC COM PAR $.01 14,978 10,867 264.36 1,107,850


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