BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2014

Position Statistics

Total Positions 102
New Positions 8
Increased Positions 28
Decreased Positions 18
Positions with Activity 46
Sold Out Positions 6
Total Mkt Value (in $ millions) 7,395

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.03%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.11%
Services
Technology
Transportation
Utilities

46 Activity Positions as of 09/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
PHARMACYCLICS INC COM 1,629,551 10,978 .68 9,656,599
SEATTLE GENETICS INC COM 700,344 109 .02 22,475,729
GENOMIC HEALTH INC COM 440,803 23 .01 13,655,618
BIOMARIN PHARMACEUTICAL INC COM 230,314 44,911 24.22 2,370,464
ANACOR PHARMACEUTICALS INC COM 158,097 35,970 29.45 4,204,702
BIOCRYST PHARMACEUTICALS COM 109,065 -1,804 (1.63) 10,713,686
DYAX CORP COM 93,044 7,201 8.39 6,157,789
XOMA CORP DEL COM 82,134 20 .02 23,071,472
CERUS CORP COM 63,761 9,044 16.53 11,940,178
XENOPORT INC COM 56,775 23,171 68.95 6,815,777
ACORDA THERAPEUTICS INC COM 31,303 -6,345 (16.85) 753,391
TG THERAPEUTICS INC COM 29,196 -1,576 (5.12) 2,050,313
CATALYST PHARM PARTNERS INC COM 24,511 16,397 202.08 6,715,462
VERSARTIS INC COM 22,093 4 .02 1,246,089
MALLINCKRODT PUB LTD CO SHS 21,395 -26,142 (54.99) 201,856
AGIOS PHARMACEUTICALS INC COM 19,694 -3,478 (15.01) 169,893
OMEROS CORP COM 17,987 1,223 7.29 808,775
INSMED INC COM PAR $.01 17,127 12,427 264.36 1,107,850
DAIICHI SANKYO CO LTD SPON ADR LEV 1 15,842 5,005 46.18 1,093,332
BLUEBIRD BIO INC COM 13,937 -4,484 (24.34) 150,000