BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 10,550

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.18%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.1%
Services
Technology
Transportation
Utilities

99 Activity Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
ABBVIE INC COM 2,421,787 -23,999 (0.98) 36,049,228
ALEXION PHARMACEUTICALS INC COM 1,364,082 116,984 9.38 7,673,730
SEATTLE GENETICS INC COM 1,353,451 47,573 3.64 28,876,712
BIOMARIN PHARMACEUTICAL INC COM 555,762 64,370 13.10 4,200,456
GENOMIC HEALTH INC COM 366,006 17 .01 13,656,942
DYAX CORP COM 155,896 -3,529 (2.21) 6,021,485
BIOCRYST PHARMACEUTICALS COM 151,096 -3,396 (2.2) 10,478,204
INVITAE CORP COM 95,768 95,768 New 6,554,967
MIRATI THERAPEUTICS INC COM 86,565 13,116 17.86 2,805,074
BELLICUM PHARMACEUTICALS INC COM 84,860 -1,886 (2.17) 4,190,594
SPARK THERAPEUTICS INC COM 75,532 75,532 New 1,327,451
CERUS CORP COM 70,748 9,660 15.81 13,553,275
XOMA CORP DEL COM 53,834 -8,108 (13.09) 14,708,613
HALOZYME THERAPEUTICS INC COM 47,751 -11,215 (19.02) 2,248,152
VERSARTIS INC COM 43,857 10,247 30.49 2,977,396
ALDER BIOPHARMACEUTICALS INC COM 41,288 34,089 473.58 879,581
ARRAY BIOPHARMA INC COM 39,951 29,828 294.67 5,658,755
XENOPORT INC COM 39,703 -2,410 (5.72) 6,508,622
INSMED INC COM PAR $.01 37,133 11,154 42.93 1,583,490
CATALYST PHARMACEUTICALS INC COM 29,581 3,324 12.66 7,565,462