BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 03/31/2015

Position Statistics

Total Positions 125
New Positions 17
Increased Positions 40
Decreased Positions 59
Positions with Activity 99
Sold Out Positions 8
Total Mkt Value (in $ millions) 11,502

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 0.9%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 93.81%
Services
Technology
Transportation
Utilities

99 Activity Positions as of 03/31/2015

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
SYNAGEVA BIOPHARMA CORP COM 2,543,257 218,110 9.38 11,660,432
PHARMACYCLICS INC COM 2,361,609 -23,403 (0.98) 9,039,652
SEATTLE GENETICS INC COM 1,248,340 43,878 3.64 28,876,712
BIOMARIN PHARMACEUTICAL INC COM 534,256 61,879 13.10 4,200,456
GENOMIC HEALTH INC COM 372,015 17 .01 13,656,942
DYAX CORP COM 160,834 -3,641 (2.21) 6,021,485
BIOCRYST PHARMACEUTICALS COM 119,661 -2,689 (2.2) 10,478,204
BELLICUM PHARMACEUTICALS INC COM 102,292 -2,273 (2.17) 4,190,594
INVITAE CORP COM 90,459 90,459 New 6,554,967
SPARK THERAPEUTICS INC COM 89,643 89,643 New 1,327,451
MIRATI THERAPEUTICS INC COM 75,204 11,394 17.86 2,805,074
CERUS CORP COM 60,448 8,253 15.81 13,553,275
XOMA CORP DEL COM 50,230 -7,566 (13.09) 14,708,613
VERSARTIS INC COM 44,095 10,303 30.49 2,977,396
ARRAY BIOPHARMA INC COM 42,554 31,772 294.67 5,658,755
XENOPORT INC COM 40,419 -2,453 (5.72) 6,508,622
HALOZYME THERAPEUTICS INC COM 39,230 -9,213 (19.02) 2,248,152
INSMED INC COM PAR $.01 35,803 10,754 42.93 1,583,490
ALDER BIOPHARMACEUTICALS INC COM 34,110 28,163 473.58 879,581
CATALYST PHARM PARTNERS INC COM 29,959 3,366 12.66 7,565,462