BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 06/30/2014

Position Statistics

Total Positions 101
New Positions 6
Increased Positions 27
Decreased Positions 15
Positions with Activity 42
Sold Out Positions 6
Total Mkt Value (in $ millions) 5,816

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.07%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.37%
Services
Technology
Transportation
Utilities

101 Positions as of 06/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
PHARMACYCLICS INC COM 1,076,267 95,789 9.77 9,591,546
SYNAGEVA BIOPHARMA CORP COM 799,106 918 .12 10,660,432
SEATTLE GENETICS INC COM 778,663 60,042 8.36 22,472,229
INCYTE CORP COM 743,466 501 .07 14,845,559
ACADIA PHARMACEUTICALS COM 533,746 New 20,481,442
GENOMIC HEALTH INC COM 442,692 24 .01 13,654,902
AVANIR PHARMACEUTICALS INC CL A NEW 202,659 139,430 220.52 18,558,487
BIOMARIN PHARMACEUTICAL INC COM 134,435 1,761 1.33 1,908,230
BIOCRYST PHARMACEUTICALS COM 126,116 58,176 85.63 10,890,872
XOMA CORP DEL COM 92,841 34 .04 23,065,972
ANACOR PHARMACEUTICALS INC COM 83,312 3,917 4.93 3,248,043
DYAX CORP COM 57,210 31,715 124.40 5,681,237
VANDA PHARMACEUTICALS INC COM 44,071 -741 (1.65) 4,372,153
CERUS CORP COM 41,499 7,255 21.19 10,246,591
MIRATI THERAPEUTICS INC COM 39,723 New 2,380,074
MALLINCKRODT PUB LTD CO SHS 38,840 -16,914 (30.34) 448,500
CLOVIS ONCOLOGY INC COM 38,479 12,769 49.67 793,221
DERMA SCIENCES INC COM PAR $.01 31,374 New 3,537,137
ACORDA THERAPEUTICS INC COM 28,787 -2,983 (9.39) 906,091
GILEAD SCIENCES INC COM 25,803 -30,225 (53.95) 256,108