BAKER BROS. ADVISORS LP Information

667 MADISON AVE, NEW YORK, New York, 10065, (212) 339-5600

Report Date: 09/30/2014

Position Statistics

Total Positions 102
New Positions 8
Increased Positions 28
Decreased Positions 18
Positions with Activity 46
Sold Out Positions 6
Total Mkt Value (in $ millions) 7,527

Institutional Holdings information is filed by major institutions on form 13-F with the Securities and Exchange Commission.

Sector Weighting

Basic Materials
Capital Goods
Conglomerates 1.04%
Consumer Cyclical
Consumer/Non-Cyclical
Energy
Financial
Healthcare 96.1%
Services
Technology
Transportation
Utilities

102 Positions as of 09/30/2014

Company Class Value of Shares ($1,000s) ▼ Change in Value ($1,000s) Change (%) Shares Held
PHARMACYCLICS INC COM 1,617,191 10,894 .68 9,656,599
SYNAGEVA BIOPHARMA CORP COM 1,284,049 New 10,660,432
INCYTE CORP COM 1,207,538 New 14,845,559
SEATTLE GENETICS INC COM 707,985 110 .02 22,475,729
ACADIA PHARMACEUTICALS COM 635,949 New 20,481,442
GENOMIC HEALTH INC COM 442,169 23 .01 13,655,618
BIOMARIN PHARMACEUTICAL INC COM 236,217 46,062 24.22 2,370,464
ANACOR PHARMACEUTICALS INC COM 162,133 36,889 29.45 4,204,702
BIOCRYST PHARMACEUTICALS COM 114,422 -1,892 (1.63) 10,713,686
DYAX CORP COM 97,231 7,525 8.39 6,157,789
XOMA CORP DEL COM 84,672 20 .02 23,071,472
CERUS CORP COM 65,193 9,247 16.53 11,940,178
XENOPORT INC COM 60,660 24,757 68.95 6,815,777
MIRATI THERAPEUTICS INC COM 50,672 New 2,380,074
VANDA PHARMACEUTICALS INC COM 49,274 New 4,372,153
HALOZYME THERAPEUTICS INC COM 40,504 New 2,776,143
ACORDA THERAPEUTICS INC COM 31,642 -6,413 (16.85) 753,391
DERMA SCIENCES INC COM PAR $.01 31,304 New 3,537,137
TG THERAPEUTICS INC COM 31,062 -1,676 (5.12) 2,050,313
PROGENICS PHARMACEUTICALS INC COM 27,811 New 4,449,797