Idenix Pharma Initiates Phase II Study - Analyst Blog
Idenix Pharmaceuticals, Inc.
) recently announced that it has initiated a phase II study
(HELIX-1: n = 90) evaluating the combination of hepatitis C virus
(HCV) infection candidates, samatasvir (IDX719) and simeprevir
(TMC435). The study is being conducted in collaboration with
Janssen Pharmaceuticals, Inc., a pharmaceutical company of
Johnson & Johnson
As monotherapy, samatasvir is being developed by Idenix Pharma and simeprevir by Johnson & Johnson in collaboration with Medivir AB.
The 12-week, randomized, double-blind and parallel group HELIX-1 study will evaluate three doses of samatasvir (50, 100, or 150 mg). The study will assess the safety and tolerability of samatasvir in combination with simeprevir and ribavirin, a widely used HCV infection drug in first-line non-cirrhotic, genotype 1b or 4 HCV-infected patients.
We remind investors that Idenix Pharma entered into a non-exclusive collaboration agreement with Johnson & Johnson, in Jan 2013, to develop HCV combination therapies. The collaboration will assess different combinations of samatasvir, simeprevir, and TMC647055 (another Johnson & Johnson's HCV candidate).
As per the terms of the agreement, Idenix Pharma will conduct the studies, while Johnson & Johnson will supply simeprevir and TMC647055 for the trials free of cost. Both the companies will not receive any milestone and royalty payments as a part of the agreement.
Idenix Pharma plans to initiate a second phase II trial (HELIX-2) on samatasvir, simeprevir and TMC647055 in the second half of 2013.
A sizeable population suffers from HCV the world over. However, the treated population is much lower. This leaves the field open for new treatments.
Both Idenix Pharma and Johnson & Johnson, currently carry a Zacks Rank #3 (Hold). Right now, companies that look well-positioned include Zacks Ranked #1 (Strong Buy) Jazz Pharmaceuticals ( JAZZ ) and Salix Pharmaceuticals, Ltd. ( SLXP ).
IDENIX PHARMA (IDIX): Free Stock Analysis Report
JAZZ PHARMACEUT (JAZZ): Free Stock Analysis Report
JOHNSON & JOHNS (JNJ): Free Stock Analysis Report
SALIX PHARM-LTD (SLXP): Free Stock Analysis Report
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