ImmunoGen, Inc. (IMGN)

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ImmunoGen, Inc. (IMGN)

Goldman Sachs 34th Annual Global Healthcare Conference Call

June 13, 2013 12:20 p.m. ET


Gregory Perry - Executive Vice President and Chief Financial Officer


Navdeep Singh - Goldman Sachs


Navdeep Singh - Goldman Sachs

Good morning everyone and thank you for attending our annual global healthcare conference. I am Navdeep Singh, one of the biotech analysts at Goldman Sachs, and it's my pleasure to introduce our next presenter Greg Perry, Executive Vice President and CFO of ImmunoGen. We encourage questions from the audience after Greg has finished with his presentation. For those on the webcast, if you have any questions, please feel free to email me at, and I will ask the quarter on your behalf.

Prior to starting the presentation, my compliance department requires me to make the following disclosures on behalf of Goldman Sachs. So there I go. We're required to make certain disclosures in the public appearances about Goldman Sachs' relationships with companies that we discuss. The disclosures relate to investment banking relationships, compensation received, or 1% or more ownership. I'm prepared to read any disclosures for any issuer now or at the end of this call if anyone would like me to; however, these disclosures are available in our most recent reports available to you as clients on our firm portal. In addition, updates to our disclosures are available by ticker on the firm's public website at http:\\\research\hedge.html. In addition, the disclosures are applicable to research with respect to issuers, if any mentioned herein, are available through your investment representative. Views of non-Goldman Sachs personnel may not represent the company’s views.

So with that, it's my pleasure to introduce Greg from ImmunoGen.

Gregory Perry

Thank you, Navdeep. I would like to just start by thanking Navdeep and Goldman Sachs for giving this opportunity to talk to you about ImmunoGen. Just as a quick reminder, there are certainly risks associated with investing in ImmunoGen. I will be making a series of forward-looking statements, and I would encourage each of you to read more about the risks associated with investing in ImmunoGen as we have disclosed more fully in our Form 10-K.

This is a very exciting time for ImmunoGen. If you think about what's happened in this past calendar year with the approval of Kadcyla, it is now commercial and selling in the U.S. This is an incredibly important event for patients, but also certainly for ImmunoGen employees and ImmunoGen shareholders. Tremendous validation of our TAP technology and ADC approach, and certainly a potential for significant economics in the form of royalties going forward.

In addition to that, what management has been spending most of its time on for the past three years is aggressively developing a proprietary pipeline. We have three programs in the clinic, soon to be four. They are all wholly-owned, and we think this represents a significant opportunity for value creation. In terms of the company itself, we are in a good financial position. Most recent financial disclosures were, we had cash of $206 million, we have no debt, and we are partnered with some of the leaders in the field of oncology, and I will talk about that in a bit.

First, I will talk about Kadcyla. Kadcyla employs ImmunoGen's proprietary TAP technology, and it's an ADC, which means it's an antibody that is linked to a highly potent cytotoxic agent. In this case here, the antibody is Genetech's Herceptin or trastuzumab antibody. It accomplished a number of firsts with its approval in the U.S. in February first, it's a first ADC approved for such a prevalent indication. In addition to that, it is a solid tumor and it's the only ADC to gain full approval in a large, randomized study.

As I mentioned, this is really a tremendous event for patients. We will talk a little bit about the efficacy and safety profile of it in a moment, but certainly for ImmunoGen's shareholders, this represents a great validation of our approach and our TAP technology and also a potential for a cash stream going forward with this royalty. And for Roche, this has turned out to be a tremendous product for them, and we believe they have positioned it to replace Herceptin, and it really epitomizes the concept of personalized medicine as we are targeting cancer cells that express a specific antigen.

So, commercialization has begun for Kadcyla. The label was pretty much as expected. Patients no longer responsive to Herceptin plus chemo, on the right hand side in the table you can see a recent publication from Roche that talked about the number of patients in the U.S., second line and later with some 14,250 and some first line about 8,000 patients. So, a very significant market. Again, Kadcyla really demonstrated the promise of Immunogen's TAP technology and that is to be more efficacious than standard of care, but with an improved side effect profile, so more tolerable, and I think that that’s really been one of the dramatic outcomes from the study and then in the approval.

Looking at the registration program and development program for Kadcyla, certainly we expect to see approvals expanding rapidly geographically. We are anticipating an approval in Europe later this year and Japan next year, and there is certainly even potential for more indication approvals. We see it being used longer in the metastatic setting given its performance, and I think really the price speaks to the value that’s perceived in Kadcyla. It was priced at some $9800 per months as compared to Herceptin at $4500 per month.

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