Coronado Biosciences, Inc.
) candidate, TSO, is currently under development for the
treatment of autoimmune diseases, such as, ulcerative colitis,
multiple sclerosis, autism, psoriasis, type I diabetes and
Coronado presented interim data from a pilot study of oral TSO
ova or CNDO-201) for the treatment of autism.
The data was presented at the American College of
Neuropsychopharmacology annual meeting.
The study enrolled 10 patients with autism spectrum disorder.
In this double-blind, randomized, placebo-controlled, cross-over
study, patients were under a 12-week treatment regimen either
with TSO or placebo. This was followed by a 4-week washout phase
and then 12 weeks of placebo or TSO treatment.
The TSO treatment was well tolerated. Interim data from the
study revealed that TSO was statistically significant in three
measures: the Montefiore-Einstein Rigidity Scale (MERS), the
Repetitive Behavior Scale-Revised (RBS-R) Sameness Scale, and the
Social Responsiveness Scale (SRS)-Repetitive Behaviors Scale. The
final results are expected in the middle of 2014.
The company suffered a setback in Oct 2013 when TSO failed to
meet both primary and secondary endpoints in its phase II study
(TRUST-I), which is evaluating TSO for the treatment of Crohn's
disease. In Nov 2013, Coronado Biosciences announced the
Independent Data Monitoring Committee Recommendation to
discontinue the Falk phase II trial of TSO in Crohn's
Earlier this month, Coronado submitted an Investigational New
Drug (IND) application to the U.S. Food and Drug Administration
(FDA) for the commencement of a phase II study of TSO to treat
moderate-to-severe chronic plaque psoriasis
The company currently does not have any marketed product.
Hence, the progress on TSO candidate is encouraging. The share
price rose 20.8% on the news.
Coronado currently carries a Zacks Rank #2 (Buy). Some
better-ranked stocks include
Aeterna Zentaris Inc.
Jazz Pharmaceuticals plc
), each carrying a Zacks Rank #1 (Strong Buy).
AETERNA ZENTARS (AEZS): Free Stock Analysis
ACTELION LTD (ALIOF): Get Free Report
CORONADO BIOSCI (CNDO): Free Stock Analysis
JAZZ PHARMACEUT (JAZZ): Free Stock Analysis
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