SAFC Commercial, the custom manufacturing services business
), declared on Sep 19 that it has added two new novel host cell
lines to its CHOZN Platform cell line, which will enhance the
utility of the CHOZN portfolio of products and services.
However, the company's shares slipped roughly 2.4% to close at
$85.93 on last Friday after its stock was downgraded by Robert W.
Baird analysts to Neutral from Outperform.
The glutamine synthetase (GS) cell line of the CHOZN platform is
specially designed to help streamlined selection, identification
and scale-up of high-producing manufacturing clones for the
production of recombinant protein drugs. It also saves weeks of
development time. Along with this, the lean chemically defined
(CD) media and feed system allows for tunable product
The new novel host cell lines in the CHOZN portfolio were
developed after rigorous research. The first novel host cell line
is the CHOZN GS host trait which is built with a knockout of the
MGAT1 gene function. This leads to early termination of the
N-glycan pathway and enables the expression of recombinant
proteins with homogeneous high Man5 glycan profiles. The host
cell line can be used for protein crystallography studies and
also for the expression of biotherapeutics.
The second novel host cell line is the CHOZN GS host trait which
is built with the knockouts of the CMAH and GGTA gene sequences.
These two genes help in the expression of recombinant proteins
that do not contain the antigenic alpha-gal and Neu5Gc moieties
on the glycan structures and makes them capable of producing
potentially safer therapeutic proteins.
Sigma-Aldrich's CHOZN portfolio includes the CHOZN Platform
(CHOZN GS CHO cell line and an optimized set of cGMP-produced, CD
media and feeds), additional CHOZN ZFN-modified cell lines, ZFN
reagents along with customization options including cell line and
media development projects.
SAFC's cGMP-produced and tested CHOZN GS cell line is powered by
Sigma-Aldrich's patented Zr Zinc Finger Nuclease (ZFN)
technology. It is the first GS knockout CHO line of its
type available in the market.
Sigma-Aldrich currently retains a Zacks Rank #3 (Hold).
Other specialty chemical companies with favorable Zacks Rank
Minerals Technologies Inc.
Sensient Technologies Corp.
). All of them hold a Zacks Rank #2 (Buy).
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